How Do Arthrosamid and Corticosteroid Injections Work?
Corticosteroid injections are well-known for their rapid anti-inflammatory effects. They work by reducing swelling and inflammation inside the knee joint, often providing fast pain relief within days. However, this relief is usually temporary, lasting only a few weeks to a few months. More importantly, corticosteroids do not halt the underlying cartilage wear and tear, and repeated use can sometimes harm cartilage further—a process called catabolism, where tissue breaks down.
Arthrosamid, on the other hand, takes a different and gentler approach. It is a hydrophilic gel made of polyacrylamide designed to blend with the natural fluid in the knee (synovial fluid). By improving joint lubrication and cushioning, it helps ease pain gradually and offers longer-lasting comfort. Importantly, Arthrosamid is “non-catabolic,” meaning it doesn’t contribute to cartilage breakdown but rather supports joint health over time. This makes it an attractive option for those seeking relief without risking further cartilage damage.
How Long Does Relief Last?
When considering injection treatments, many people want to know: how long can I expect the benefits to last?
Corticosteroid injections typically deliver noticeable relief quickly, but this tends to fade within a few months. A recent study comparing corticosteroids with hyaluronic acid injections found that corticosteroids “offered clinically relevant benefits compared to hyaluronic acid at short term, while hyaluronic acid provided superior functional improvement at long term.” Though this study did not include Arthrosamid specifically, the findings reflect a common pattern with corticosteroids—fast but fleeting effects.
Arthrosamid is designed to offer more sustained improvement, cushioning the joint and supporting function over a longer period. While direct head-to-head comparisons with corticosteroids are limited, research has shown Arthrosamid can provide ongoing pain relief and improved mobility for many months, even up to two years. This longer duration of comfort means fewer injections and a steadier quality of life for patients.
Impact on Everyday Life and Planning
Living with knee osteoarthritis often involves managing unpredictability. Sudden flare-ups of pain can disrupt plans, making it difficult to commit to activities ahead of time. Corticosteroid injections may ease symptoms quickly but can lead to a rollercoaster of relief and return of pain, making it hard to maintain a steady lifestyle.
In contrast, the sustained effect of Arthrosamid offers a more reliable baseline of comfort. This stability helps patients move more freely and plan their days with greater confidence—whether that’s exercising, socialising, or simply getting through daily tasks. As highlighted in research, the “symptomatic trajectory after 36 months showed no worsening in knee OA patients undergoing intra-articular injections, with different benefits based on the treatments.” Choosing treatments that prioritise continuity of relief supports better everyday function and improved quality of life.
Why Clinical Expertise Matters
Deciding which injection therapy is right requires more than a simple choice—it demands expert assessment tailored to each person’s unique situation. Professor Paul Lee, with his extensive knowledge of cartilage biology and orthopaedic rehabilitation, emphasises that factors such as the severity of osteoarthritis, general health, and personal goals should guide treatment decisions.
At MSK Doctors, patients benefit from an environment where personalised care is at the centre of everything. Open discussions, thorough assessments, and a holistic view of each patient’s needs ensure that treatments like Arthrosamid or corticosteroids are used thoughtfully and safely. This level of expertise is critical to achieving the best possible outcomes and maintaining joint health for the long haul.
In Summary
Arthrosamid and corticosteroid injections each play important roles in managing knee osteoarthritis. Corticosteroids offer quick, short-term relief by tackling inflammation, but their effects are temporary and may carry risks with repeated use. Arthrosamid provides a different path—a non-catabolic gel that cushions the joint, aiming for longer-lasting comfort and protection of cartilage.
For those seeking sustained relief that supports everyday function and allows better planning of life’s demands, Arthrosamid stands out as an appealing option. Ultimately, the best choice depends on individual factors and is best made with the help of experienced healthcare professionals like Professor Paul Lee and the MSK Doctors team.
If you suffer from knee osteoarthritis and want to explore treatment options tailored to you, seek advice from a qualified healthcare provider.
References
Bensa, A., Bianco Prevot, L., Peretti, G., & Filardo, G. (2025). Effect of corticosteroids and hyaluronic acid injections on knee osteoarthritis trajectory. Journal of Experimental Orthopaedics, 12(3). https://doi.org/10.1002/jeo2.70333
Frequently Asked Questions
Arthrosamid acts as a non-catabolic gel improving joint cushioning and lubrication, delivering gradual, long-lasting relief. Corticosteroid injections primarily reduce inflammation, giving rapid but temporary pain relief. MSK Doctors offer expert guidance to choose the right option for individual needs.
Corticosteroid injections usually provide relief for a few weeks or months. Arthrosamid, however, is designed to offer sustained comfort, with research showing benefits lasting many months, even up to two years. Professor Paul Lee can advise further at MSK Doctors.
Arthrosamid’s sustained effect helps provide stable relief, enabling better planning and participation in daily tasks. Corticosteroids may cause fluctuating pain levels. MSK Doctors focus on tailoring treatment to support your mobility and lifestyle goals under Professor Paul Lee’s guidance.
Careful assessment is necessary, as suitability depends on arthritis severity, health, and personal goals. Professor Paul Lee, a cartilage expert and Royal College of Surgeons advisor, ensures patients receive personalised care at MSK Doctors, leading to optimised outcomes and joint health.
Professor Paul Lee brings recognised expertise in cartilage and joint health, supported by his ambassador and advisory roles. MSK Doctors emphasise personalised, evidence-based care, helping each patient make informed decisions and achieve the best results for their knee osteoarthritis management.
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